Arthur I Cederbaum Selected Research

Cytochrome P-450 CYP2E1 (CYP2E1)

1/2016	The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.
1/2015	Synergistic toxic interactions between CYP2E1, LPS/TNFα, and JNK/p38 MAP kinase and their implications in alcohol-induced liver injury.
1/2014	HBx inhibits CYP2E1 gene expression via downregulating HNF4α in human hepatoma cells.
10/2013	Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo.
1/2013	Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK.
9/2012	Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy.
9/2012	Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver.
1/2012	CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment.
1/2012	CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases.
11/2010	Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice.

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Arthur I Cederbaum Research Topics

Disease

16	Necrosis 10/2015 - 02/2002
10	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2018 - 07/2003
7	Mitochondrial Diseases (Mitochondrial Disease) 01/2015 - 02/2002
7	Fatty Liver 10/2013 - 05/2008
5	Hepatocellular Carcinoma (Hepatoma) 01/2014 - 01/2004
5	Infections 07/2004 - 01/2002
4	Alcoholic Fatty Liver 01/2019 - 05/2008
4	Fibrosis (Cirrhosis) 01/2017 - 01/2002
4	Inflammation (Inflammations) 08/2013 - 11/2003
4	Obesity 01/2013 - 12/2003
3	Liver Cirrhosis (Hepatic Cirrhosis) 01/2016 - 04/2003
2	Hypertriglyceridemia 01/2017 - 10/2011
2	Hypoxia (Hypoxemia) 10/2013 - 01/2002
2	Hemorrhage 09/2009 - 04/2007
2	Liver Diseases (Liver Disease) 10/2006 - 02/2006
2	Ischemia 01/2006 - 01/2005
2	Neoplasms (Cancer) 03/2005 - 02/2003
1	Malnutrition (Nutritional Deficiencies) 01/2018
1	Wounds and Injuries (Trauma) 01/2016
1	Drug-Related Side Effects and Adverse Reactions 01/2015
1	Chronic Hepatitis B 01/2014
1	Disease Progression 09/2012
1	Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis) 05/2008
1	Alcoholic Hepatitis 05/2008
1	Body Weight (Weight, Body) 04/2006
1	Myocardial Reperfusion Injury 02/2006
1	Carcinogenesis 12/2004
1	Hyperlipidemias (Hyperlipidemia) 05/2004

Drug/Important Bio-Agent (IBA)

24	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 01/2016 - 04/2002
20	Ethanol (Ethyl Alcohol)IBA 01/2018 - 07/2003
8	Oxidants (Oxidizing Agents)IBA 01/2012 - 01/2002
7	Transaminases (Aminotransferases)IBA 01/2016 - 04/2006
6	pyrazoleIBA 01/2012 - 08/2005
4	Proteins (Proteins, Gene)FDA Link 05/2007 - 02/2003
4	AntioxidantsIBA 05/2004 - 01/2002
4	CatalaseIBA 12/2003 - 01/2002
3	Nicotine FDA Link 01/2019 - 08/2013
3	Pharmaceutical PreparationsIBA 01/2017 - 11/2003
3	Glucose (Dextrose)FDA LinkGeneric 10/2015 - 09/2009
3	Phosphotransferases (Kinase)IBA 01/2015 - 06/2010
3	Adenosine Triphosphate (ATP)IBA 01/2013 - 02/2002
3	Superoxide Dismutase-1IBA 10/2011 - 11/2003
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 02/2003
2	CotinineIBA 01/2019 - 11/2018
2	CytochromesIBA 01/2018 - 09/2012
2	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2016 - 09/2005
2	S-Adenosylmethionine (Ademetionine)IBA 01/2012 - 09/2005
2	Fatty Acids (Saturated Fatty Acids)IBA 05/2008 - 02/2002
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 02/2006 - 08/2005
2	Glutathione (Reduced Glutathione)IBA 07/2004 - 12/2003
2	Superoxide DismutaseIBA 12/2003 - 11/2003
1	EnzymesIBA 11/2018
1	Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))IBA 01/2018
1	ApigeninIBA 01/2017
1	fibroblast growth factor 21IBA 01/2017
1	Thioacetamide (Thioacetamid)IBA 01/2016
1	Protein Isoforms (Isoforms)IBA 01/2015
1	pimonidazoleIBA 10/2013
1	CollagenIBA 08/2013
1	Sirolimus (Rapamycin)FDA Link 01/2013
1	CarcinogensIBA 01/2013
1	AdiponectinIBA 09/2012
1	CytokinesIBA 09/2012
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2012
1	Alanine Transaminase (SGPT)IBA 11/2011
1	Small Interfering RNA (siRNA)IBA 10/2011
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 10/2011
1	Docosahexaenoic AcidsIBA 10/2011
1	Collagen Type I (Type I Collagen)IBA 11/2010
1	Acyl-CoA OxidaseIBA 11/2010
1	Peroxynitrous Acid (Peroxynitrite)IBA 06/2010
1	NF-kappa B (NF-kB)IBA 06/2010
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2010
1	PPAR alphaIBA 05/2008
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2008
1	Triglycerides (Triacylglycerol)IBA 07/2007
1	Caspase 3 (Caspase-3)IBA 07/2007
1	AcetoneIBA 06/2007
1	Adenine NucleotidesIBA 05/2007
1	CalciumIBA 01/2007
1	Phospholipases A2 (Phospholipase A2)IBA 02/2006
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2006
1	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2005
1	alpha2 Subunit Collagen Type IIBA 09/2005
1	Superoxides (Superoxide)IBA 08/2005
1	Phorbol EstersIBA 03/2005
1	Protein Kinase CIBA 03/2005
1	EndotoxinsIBA 01/2005
1	amsonic acid (DAS)IBA 12/2004
1	allyl sulfideIBA 12/2004
1	Acetaminophen (Paracetamol)FDA LinkGeneric 07/2004
1	Thiobarbituric Acid Reactive SubstancesIBA 05/2004
1	Chelating AgentsIBA 05/2004
1	Deferoxamine (Desferal)FDA LinkGeneric 05/2004
1	IronIBA 05/2004
1	LipidsIBA 05/2004
1	Vitamin E FDA LinkGeneric 05/2004
1	Glutamate-Cysteine LigaseIBA 12/2003
1	Glutathione Reductase (Glutathione-Disulfide Reductase)IBA 12/2003

Therapy/Procedure

1	Injections 01/2016